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High dosage of prednisone is likely to cause some side effects as mentioned below: Studies found that the use of corticosteroids during pregnancy moderately increases the risk of cleft lip (7)(8)and cleft palate (9). In addition, the use of prednisone in pregnancy was the subject of an investigation, which reported that the use of corticosteroids in pregnancy increases the risk of cleft palate in the neonate and may be associated with a decreased quality of life. (See the reference "Pregnancy and pregnancy hormones: Potential effects on the fetus from corticosteroid treatment" at www.ncbi.nlm.nih.gov/pubmed/?term=prednisone) Pregnancy hormones: Several studies have found estrogen to be a likely trigger for certain side effects, including miscarriage and stillbirth (e.g., http://www.ncbi.nlm.nih.gov/pubmed/14296873), an increase in the risk of cardiovascular diseases, cancer, and cardiovascular dysfunction, cardiovascular failure, stroke, asthma, and skin and soft tissue injury (10). In addition, research indicates that low or high doses of progestogens have been found to have a role in the early development of male breast tissue. Progestogen-containing formulations: Several studies found in vitro studies that progestogen-containing formulations and formulations containing a progestogen may increase the risk for miscarriage and pre-eclampsia (11), increased uterine bleeding, and increased blood pressure. While the risk for miscarriage in such formulations is relatively small, the potential for this risk increases with the duration of pregnancy (e.g., http://www.ncbi.nlm.nih.gov/pubmed/20337591) and the dose (12). The progestogen-containing estrogen-containing formulations used by pregnant women may interact with certain immunosuppressant medications on the level of progestogen production at different dosage levels, and this may increase the risks for miscarriage in the offspring. (See the reference "Progestogen-Packing Diets, Contraceptive Drugs, and Immunosuppressants Used by Pregnant Women" at www.ncbi.nlm.nih.gov/pubmed/16235053) Treatment of miscarriage or pre-eclampsia while pregnant may increase the risk for a number of illnesses, including asthma, diabetes that worsens with maternal smoking (e.g., http://www.ncbi.nlm.nih.gov/pubmed/24239899), and diabetes, kidney stones, blood clots, and anemia (13). T Similar articles: